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Cold Spring Harb Perspect Med. 2011 Sep; 1(1): a008862. doi: 10.1101/cshperspect.a008862 PMCID: PMC3234454 PMID: 22229124 The History of Parkinson's Disease: Early Clinical Descriptions and Neurological Therapies Christopher G. Goetz Author information Copyright and License information PMC Disclaimer Go to: Abstract Although components of possible Parkinson's disease can be found in very early documents, the first clear medical description was written in 1817 by James Parkinson. In the mid-1800s, Jean-Martin Charcot was particularly influential in refining and expanding this early description and in disseminating information internationally about Parkinson's disease. He separated Parkinson's disease from multiple sclerosis and other disorders characterized by tremor, and he recognized cases that later would likely be classified among the Parkinsonism-plus syndromes. Early treatments of Parkinson's disease were based on empirical observation, and anticholinergic...
